Modafinil Vs. Vyvanse - Which one is a better Option?

In researching nootropics, it’s likely that most people have come across the most popular nootropics, Modafinil and Vyvanse.

These two medications effectively work to treat the symptoms of sleep disorders and Attention Deficit Hyperactivity Disorder.

This blog delves into the detailed comparison of Modafinil Vs. Vyvanse

Modafinil and Vyvanse: An Overview 

Modafinil is a pharmaceutical drug that belongs to the Schedule IV controlled substance and belongs to the Eugeroic group ( a group that promotes wakefulness properties).  The FDA approved the use of  Modafinil in 1998. 

It is a powerful stimulant that helps to treat sleep disorders like narcolepsy, obstructive sleep apnea, and shift work sleep disorders. 200 mg is the standard recommended dosage of Modafinil, though it might vary from person to person. The maximum dosage of Modafinil is 400mg/day. Consumption of more than the prescribed dosage might lead to a Modafinil overdose. [1].

Vyvanse is the brand name used for the generic Lisdexamfetamine. It is a central nervous system stimulant that affects the chemicals in the brain and nerves that contribute to hyperactivity and impulse control. The FDA approved the use of modafinil to treat Attention Deficit Hyperactivity Disorder (ADHD). It also helps with psychological, social, and other problems. You should never use the medication to lose weight [2].

Similarities between Modafinil and Vyvanse 

Modafinil and Vyvanse (central nervous system stimulants) carry the following similarities along with them:

1. Both Vyvanse and Modafinil are Category C drugs for the stage of pregnancy and breastfeeding. 

2. The use of both the drugs is approved by the FDA. 

However, both the medications are suggested to be taken only after consultations with the doctor [3].

Dissimilarities between Vyvanse Vs. Modafinil

There are a few notable differences between Vyvanse and Modafinil. They are as follows:

Generic and Brand Name 

Vyvanse is a brand name used for the generic Lisdexamfetamine. However, Modafinil 200 mg is generic and is available under different brand names, such as Modalert and Modvigil. 

The manufacturer of Modafinil is Cephalon Inc., which has now been acquired by Teva Pharmaceutical Industries  Pvt. Ltd. 

In comparison,  the manufacturer of Vyvanse is Takeda Pharmaceutical Company Limited, U.S.A.

Drug Class 

Both the medications (Modafinil and Vyvanse) belong to the stimulant drug class. Modafinil belongs to the non-amphetamine group, whereas Vyvanse is classified as amphetamine.

Structural Differences Between Modafinil And Vyvanse 

The molecular formula of Modafinil is C15H15NO2S. On the other hand, the molecular formula of Lisdexamfetamine is C15H25N3O.

Mechanism Of Action Of Lisdexamfetamine And Modafinil 

Vyvanse works by blocking the reuptake of dopamine and norepinephrine in the central nervous system. Both of these neurotransmitters contribute to helping increase focus, motivation, alertness, effort, and sustaining thoughts. Modafinil's working mechanism includes inhibiting the reuptake of dopamine and increasing its level in the body. It also has the potency to increase histamine (HA), norepinephrine (NE), serotonin (5-HT), and orexin levels in the brain. 

Modafinil Vs. Vyvanse: Which Is More Affordable?

Modafinil is more affordable, as the price of Vyvanse, according to the website Single Care, is $15 per pill, whereas the price of Modafinil is $ 1.06 per pill at the reputable online pharmacy Healthmatter.

Potential Side Effects of Modafinil Vs. Vyvanse

 The potential side effects of the medicines are listed below for you to consider before choosing the right option:

10 important Modafinil Side Effects are given below:

1. Skin rashes. 

2. Headache.

3. Fever.

4. Difficulty breathing.

5. Anxiety.

10 Potential Side Effects of Vyvanse are listed below:

1. Nausea.

2. Constipation.

3. Sweating.

4. Weight loss.

5. Irritability. 

If any of the symptoms are severe in nature, you can consult your doctor or visit a nearby hospital. 

The side effects of Modafinil are well tolerated compared to Vyvanse; therefore, it is always Modafinil over Vyvanse. 

How to choose the right medication: Vyvanse Vs.Modafinil

To choose the right medication, it is important for you to consider your individual needs and preferences. 

Vyvanse is specifically considered to be more effective in treating ADHD, while Modafinil is generally considered to be more effective in treating sleep disorders. Additionally, Vyvanse can cause more side effects than Modafinil, so it is important to weigh the potential risks and benefits of each medication before making a decision. However, you should always consult your doctor before taking any medication. 

Modafinil Vs. Vyvanse:  Conclusion 

Modafinil and Vyvanse are two similar drugs, but they differ in certain factors.

But if we have to choose one drug between the two, then we would definitely choose Modafinil because Vyvanse has an increased risk of adverse events and may cause dependency. On the other hand, Modafinil has a lower risk of dependency and is generally well tolerated among most people.